ABSTRACT
Objective: to determine the diagnostic accuracy of doppler ultrasonography for diagnosing esophageal varices in cirrhotic patients taking endoscopic findings as gold standard
Material and Methods: one hundred and thirty five patients fulfilling inclusion criteria underwent doppler ultrasound of abdomen for esophageal varices. This was followed by upper GI endoscopy in all patients. Data was analyzed for sensitivity, specificity, positive predictive values, negative predictive values and accuracy rate of doppler ultrasonography for diagnosing esophageal varices
Results: frequency of esophageal varices in cirrhotic patients on endoscopy was 62.22 % [n=84 ]. Diagnostic accuracy of doppler ultrasonography for diagnosing esophageal varices in cirrhotic patients taking endoscopy as gold standard was recorded. Results showed that 51.85% [n=70] were true positive, 2.96% [n=4] false positive, 34.81% [n=47] true negative and 10.37% [n=14] false negative. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy rate were calculated as 83.33%, 92.16%, 94.59%, 77.05% and 86.67% respectively
Conclusion: the diagnostic accuracy of Doppler Ultrasonography for diagnosing esophageal varices in cirrhotic patients' standard is high
ABSTRACT
Objectives: To determine the etiological spectrum in patients of Liver cirrhosis presenting to a tertiary care hospital of Pakistan
Study: A descriptive case series conducted from December, 2006 to December, 2007 at Services Hospital Lahore
Patients and Methods: One hundred patients of liver cirrhosis presenting in emergency or outpatient department of Services Hospital Lahore, were enrolled. Diagnosis of cirrhosis was made by combination of clinical and ultrasonographic findings. ELISA testing for Hepatitis B surface antigen and Hepatitis C virus antibodies was performed
Results: Amongst the 100 patients 59% were male and 41% were females, majority of these had urban [82%] background. The etiology of cirrhosis was mainly viral [83%], out of which 81% had hepatitis C, 1% hepatitis B and 1% both hepatitis B and hepatitis C. The mean age [years] was 55.79 +/- 13.545 [SD] and mean weight [kilograms] was 62.49 +/- 8.02 [[SD]
Conclusion: We conclude that etiology of Liver Cirrhosis is mainly Hepatitis C in our areas and males are more vulnerable to acquire
ABSTRACT
Objective: to determine the frequency of paraneoplastic manifestations in patients with hepatocellular carcinoma [HCC] presenting at tertiary care center
Design: descriptive study
Place of study: department of Gastroenterology - Hepatology, Shaikh Zayed Federal Post Graduate Medical Institute, Lahore
Patients and Methods: patients of hepatocellular carcinoma were interviewed for symptoms suggestive of paraneoplastic manifestations of HCC. The patients were subsequently examined and investigated. The frequency of paraneoplastic features was determined using SPSS 13.0
Results: of the total 100 patients included, musculoskeletal involvement with joint pain [11%] and muscle tenderness [4%] was noted. Skin lesions were noted in 2% of patients. On investigation 1% patient had erythrocytosis, 3% had thrombocytosis and eosinophilia was noted in 10% of patients. Calcium and cholesterol level were raised in 7% of patients each
Conclusions: paraneoplastic features are seen in significant number of patients with hepato cellular carcinoma